Pep2m, myristoylated (TFA)

Pep2m, myristoylated TFA (Myr-Pep2m TFA) is a cell-permeable peptide. Pep2m, myristoylated TFA can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC) [1][2].

Product Specifications

Product Name Alternative

Myr-Pep2m (TFA)

UNSPSC

12352209

Target

PKC

Type

Peptides

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pep2m-myristoylated-tfa.html

Purity

99.77

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(N)CC[C@@H](C(O)=O)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCSC)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F

Molecular Formula

C65H119F3N18O16S

Molecular Weight

1497.83

References & Citations

[1]Yudong Yao, et al. PKMζ Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors. J Neurosci. 2008 Jul 30; 28 (31) : 7820-7827.|[2]Nicole C George, et al. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain. 2019; 15: 1744806919840582.