CLK1-IN-3

CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A. CLK1-IN-3 also shows a relatively potent inhibition against Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. CLK1-IN-3 potently induces autophagy in vitro. CLK1-IN-3 can be used for acute liver injury (ALI) research[1].

Product Specifications

CAS Number

[2922550-28-3]

UNSPSC

12352005

Target

Autophagy; CDK; DYRK

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/clk1-in-3.html

Purity

98.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1CCN(CC1)C2=CC=C(C=C2)C(NC3=CN=C4NC=C(C4=C3)C5=CN=CC(F)=C5)=O

Molecular Formula

C24H23FN6O

Molecular Weight

430.48

References & Citations

[1]Yang T, et al. Rational design and appraisal of selective Cdc2-Like kinase 1 (Clk1) inhibitors as novel autophagy inducers for the treatment of acute liver injury (ALI) . Eur J Med Chem. 2023 Mar 15;250:115168.