Norwogonin-8-O-glucuronide

Norwogonin-8-O-glucuronide is a glucuronide that can be isolated from Scutellaria indica. Norwogonin-8-O-glucuronide has anti-inflammatory activity. Norwogonin-8-O-glucuronide is a flavone glycoside. Norwogonin-8-O-glucuronide inhibits NO production in macrophage RAW264.7 cells with an IC50 above 30 μM[1][2].

Product Specifications

CAS Number

[118525-47-6]

UNSPSC

12352005

Target

NO Synthase; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/norwogonin-8-o-glucuronide.html

Purity

98.90

Solubility

10 mM in DMSO

Smiles

O=C(C=C(C1=CC=CC=C1)O2)C(C2=C3O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(O)=O)=C(C=C3O)O

Molecular Formula

C21H18O11

Molecular Weight

446.36

References & Citations

[1]Cuong TD, et al. Anti-inflammatory activity of phenolic compounds from the whole plant of Scutellaria indica. Bioorg Med Chem Lett. 2015 Mar 1;25 (5) :1129-34.|[2]Zuo, R., et al., (2016) . Metabolic fate analysis of Huang-Lian-Jie-Du Decoction in rat urine and feces by LC-IT-MS combining with LC-FT-ICR-MS: a feasible strategy for the metabolism study of Chinese medical formula. Xenobiotica; the fate of foreign compounds in biological systems, 46 (1), 65–81.