WLSEAGPVVTVRALRGTGSW

WLSEAGPVVTVRALRGTGSW is a cardiomyocyte specific peptide. WLSEAGPVVTVRALRGTGSW-expressing exosomes can improve specific uptake by cardiomyocytes, decrease cardiomyocyte apoptosis, and enhance cardiac retention following intramyocardial injection in vivo[1][2].

Product Specifications

CAS Number

[771479-86-8]

UNSPSC

12352209

Target

Apoptosis

Type

Peptides

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/wlseagpvvtvralrgtgsw.html

Purity

98.38

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1N(CCC1)C(CNC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](N)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O)=O)N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CO)C(N[C@H](C(O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C97H152N28O27

Molecular Weight

2142.42

References & Citations

[1]McGuire MJ, et, al. In vitro selection of a peptide with high selectivity for cardiomyocytes in vivo. J Mol Biol. 2004 Sep 3;342 (1) :171-82.|[2]Mentkowski KI, et, al. Exosomes Engineered to Express a Cardiomyocyte Binding Peptide Demonstrate Improved Cardiac Retention in Vivo. Sci Rep. 2019 Jul 11;9 (1) :10041.