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Tiapride (hydrochloride)

Tiapride hydrochloride is a selective and orally active D2 and D3 dopamine receptors antagonist with IC50 values of 110-320 nM and 180 nM, respectively. Tiapride hydrochloride shows anti-dyskinetic activity and anxiolytic activity. Tiapride hydrochloride is a neuroleptic agent[1][2].

Product Specifications

CAS Number

51012-33-0

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tiapride-hydrochloride.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 31.25 mg/mL (ultrasonic) |H2O : ≥ 200 mg/mL

Smiles

O=C(NCCN(CC)CC)C1=CC(S(=O)(C)=O)=CC=C1OC.[H]Cl

Molecular Formula

C15H25ClN2O4S

Molecular Weight

364.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Scatton B, et al. The preclinical pharmacologic profile of tiapride. Eur Psychiatry. 2001 Jan;16 Suppl 1:29s-34s.|[2]Peters DH, et al. Tiapride. A review of its pharmacology and therapeutic potential in the management of alcohol dependence syndrome. Drugs. 1994 Jun;47 (6) :1010-32.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

D2 Receptor; D3 Receptor

Available Sizes

Frequently Asked Questions

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