EPZ020411 (hydrochloride)
EPZ020411 hydrochloride is a selective inhibitor of PRMT6 with an IC50 of 10 nM, it has >10 folds selectivity for PRMT6 over PRMT1 and PRMT8. EPZ020411 hydrochloride can be used for the research of cancer[1][2].
Product Specifications
CAS Number
2070015-25-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Histone Methyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/EPZ020411-hydrochloride.html
Purity
98.15
Solubility
0.1 M HCl : 50 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C) |DMSO : 50 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CNCCN(C)CC1=CNN=C1C2=CC=C(O[C@H]3C[C@H](OCCC4CCOCC4)C3)C=C2.Cl[H]
Molecular Formula
C25H39ClN4O3
Molecular Weight
479.06
Precautions
H302, H315, H319, H335
References & Citations
[1]Mitchell LH, et al. Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 ToolCompound. ACS Med Chem Lett. 2015 Apr 6;6 (6) :655-659.|[2]He Y, et al. Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death. Theranostics. 2020 Jan 1;10 (1) :133-150.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT1; PRMT6; PRMT8
Citation 01
J Immunother Cancer. 2025 Mar 13;13 (3) :e010639.|Acta Pharmacol Sin. 2022 Feb;43 (2) :457-469.|Bioorg Chem. 2024 May 10:148:107439.|Brain. 2024 Jul 5;147 (7) :2552-2565.|Cell Death Dis. 2023 Oct 9;14 (10) :655.|EMBO Rep. 2018 Dec;19 (12) :e46377.|Exp Cell Res. 2022 Nov 16;422 (1) :113413.|J Transl Med. 2024 Oct 10;22 (1) :922.|J Transl Med. 2025 Jan 16;23 (1) :74.
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC040009-100 1x 100 µL
MART-1 / Melan-A (M2-7C10), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC041081-500 1x 500 µL
CD45RO (190-2F2.5), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC741897-500 1x 500 µL
Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) (rCALD1/820), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881705-500 1x 500 µL
TCF4 (Transcription Factor 4) (TCF4/1705), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC882867-500 1x 500 µL
CD59 / Complement Regulatory Protein / Protectin (MACIF/2867R), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details