Sulfamethoxazole-13C6

Sulfamethoxazole-13C6 (Ro 4-2130-13C6) is a 13C labeled Sulfamethoxazole (HY-B0322) . Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis[1][2][3].

Product Specifications

CAS Number

[1196157-90-0]

Product Name Alternative

Ro 4-2130-13C6

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H335, H361

Target

Antibiotic; Bacterial; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sulfamethoxazole-13c6.html

Purity

99.91

Solubility

10 mM in DMSO|DMSO : ≥ 100mg/mL|H2O : 0.1mg/mL (ultrasonic)

Smiles

O=[S](NC1=NOC(C)=C1)([13C]([13CH]=[13CH]2)=[13CH][13CH]=[13C]2N)=O

Molecular Formula

C4 13C6H11N3O3S

Molecular Weight

259.23

Precautions

H315, H317, H319, H335, H361

References & Citations

[1]Zambuzzi-Carvalho et al. Transcriptional profile of the human pathogenic fungus Paracoccidioides lutzii in response to sulfamethoxazole. Med Mycol. 2015;53 (5) :477-492. |[2]Choonara BF, et al. A menthol-based solid dispersion technique for enhanced solubility and dissolution of sulfamethoxazole from an oral tablet matrix. AAPS PharmSciTech. 2015 Aug;16 (4) :771-86.|[3]Ogata H, et al. Dose Dependent Effect of Sulfamethoxazole on Inhibiting KATP Channel of Mouse Pancreatic β Cell. Dose Response. 2023 Sep 28;21 (3) :15593258231203611.