D-Threonine

D-Threonine (H-D-Thr-OH) is one of the important unnatural amino acids used as chiral building blocks in pharmaceutical drugs. D-Threonine is a metabolite of Saccharomyces cerevisiae. D-Threonine is cleaved into glycine and acetaldehyde by the catalytic action of D-threonine aldolase[1][2][3].

Product Specifications

CAS Number

[632-20-2]

Product Name Alternative

H-D-Thr-OH

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Drug Intermediate; Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/d-threonine.html

Purity

98.0

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC([C@@H]([C@@H](O)C)N)=O

Molecular Formula

C4H9NO3

Molecular Weight

119.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Ito T, et al. Enzymatic assay of D-serine using D-serine dehydratase from Saccharomyces cerevisiae. Anal Biochem. 2007 Dec 15;371 (2) :167-72. |[2]Kataoka M, et al. Isolation and characterization of D-threonine aldolase, a pyridoxal-5'-phosphate-dependent enzyme from Arthrobacter sp. DK-38. Eur J Biochem. 1997 Sep 1;248 (2) :385-93. |[3]Han SW, Shin JS. Preparation of D-threonine by biocatalytic kinetic resolution. Journal of Molecular Catalysis B: Enzymatic. 2015 Dec 1;122:227-32.