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(Z) -SU5614

(Z) -SU5614 is a potent FLT3 inhibitor and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3[1].

Product Specifications

CAS Number

[1055412-47-9]

UNSPSC

12352005

Hazard Statement

H302, H413

Target

Apoptosis; FLT3

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-su5614.html

Purity

98.09

Solubility

DMSO : 13.89 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NC2=C(C=C(Cl)C=C2)/C1=C/C3=C(C)C=C(C)N3

Molecular Formula

C15H13ClN2O

Molecular Weight

272.74

Precautions

H302, H413

References & Citations

[1]Spiekermann K, et al. The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood. 2003 Feb 15;101 (4) :1494-504.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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