NCT-505

NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM) .

Product Specifications

CAS Number

[2231079-74-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Aldehyde Dehydrogenase (ALDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NCT-505.html

Purity

99.37

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1(C2=CC=CC=C2)CCN(C3=C(C(N4CCN(S(=O)(C)=O)CC4)=O)C=NC5=CC=C(F)C=C35)CC1

Molecular Formula

C27H28FN5O3S

Molecular Weight

521.61

Precautions

H302, H315, H319

References & Citations

[1]Yang SM, et al. Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity. J Med Chem. 2018 Jun 14;61 (11) :4883-4903.