BCAT-IN-2
BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6) . BCAT-IN-2 can be used for the research of obesity and dislipidema[1].
Product Specifications
CAS Number
1800024-45-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aminotransferases (Transaminases)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bcat-in-2.html
Concentration
10mM
Purity
99.07
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC1=C2NC(CCC)=CC(N2N=C1NCC3=C(F)C=C(Cl)C=C3F)=O
Molecular Formula
C17H14ClF2N5O
Molecular Weight
377.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Bertrand SM, et, al. The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits. J Med Chem. 2015 Sep 24;58 (18) :7140-63.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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