VVD-130037

VVD-130037 (BAY-3605349) is an orally active covalent activator of KEAP 1 (Kelch-like ECH-associated protein 1) with anti-tumor activity. VVD-130037 degrades NRF2 (nuclear factor-erythroid 2 p45-related factor 2), resulting in significant inhibition of tumor growth in advanced solid tumors[1][2][3].

Product Specifications

CAS Number

[3034880-93-5]

Product Name Alternative

BAY-3605349

UNSPSC

12352005

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vvd-130037.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=NC(C2=CC(Cl)=CC([C@@H]3COCCN3C(C=C)=O)=C2)=NC=C1

Molecular Formula

C17H17ClN4O2

Molecular Weight

344.80

References & Citations

[1]Chan Shan, et al. The Crosstalk between Autophagy and Nrf2 Signaling in Cancer: from Biology to Clinical Applications. Int J Biol Sci. 2024 Nov 11;20 (15) :6181-6206.|[2]Gu X, et al. The Cancer Antioxidant Regulation System in Therapeutic Resistance. Antioxidants (Basel) . 2024 Jun 27;13 (7) :778.|[3]Han B, et al. Tumor suppressor KEAP1 promotes HSPA9 degradation, controlling mitochondrial biogenesis in breast cancer. Cell Rep. 2024 Jul 23;43https://pubmed.ncbi.nlm.nih.gov/39003742/ (7) :114507.