VVD-130037
Product Specifications
UNSPSC Description
VVD-130037 is an orally active covalent activator of KEAP (Kelch-like ECH-associated protein 1). VVD-130037 degrades NRF2 (nuclear factor-erythroid 2 p45-related factor 2), resulting in significant inhibition of tumor growth in advanced solid tumors[1].
Target Antigen
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/vvd-130037.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=NC(C2=CC(Cl)=CC([C@@H]3COCCN3C(C=C)=O)=C2)=NC=C1
Molecular Weight
344.80
References & Citations
[1]Chan Shan, et al. The Crosstalk between Autophagy and Nrf2 Signaling in Cancer: from Biology to Clinical Applications. Int J Biol Sci. 2024 Nov 11;20(15):6181-6206.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159641/VVD-130037-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159641/VVD-130037-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
3034880-93-5
Available Sizes
Curated Selection
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