Nabumetone

Nabumetone is an orally active non-acidic anti-inflammatory agent, acts as a potent and selective COX-2 inhibitor, and is the proagent of the active metabolite 6MNA.

Product Specifications

CAS Number

[42924-53-8]

Product Name Alternative

BRL14777

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Nabumetone.html

Purity

99.94

Solubility

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

Smiles

CC(CCC1=CC=C2C=C(OC)C=CC2=C1)=O

Molecular Formula

C15H16O2

Molecular Weight

228.29

Precautions

H315, H319, H320

References & Citations

[1]Vural F, et al. Cyclo-oxygenase 2 inhibitor, nabumetone, inhibits proliferation in chronic myeloid leukemia cell lines. Leuk Lymphoma. 2005 May;46 (5) :753-6.|[2]Melarange R, et al. Anti-inflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6MNA (6-methoxy-2-naphthylacetic acid) : comparison with indomethacin. Agents Actions. 1992; Spec No:C82-3.