KRA-533
KRA-533 is a potent KRAS agonist. KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells.
Product Specifications
CAS Number
10161-87-2
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kra-533.html
Concentration
10mM
Purity
98.73
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(CCCCNC(CBr)=O)C=C1
Molecular Formula
C13H16BrNO3
Molecular Weight
314.18
References & Citations
[1]Xu K, et al. Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy [published correction appears in Mol Cancer. 2020 May 20;19 (1) :93]. Mol Cancer. 2019;18 (1) :85. Published 2019 Apr 10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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