KRA-533

KRA-533 is a potent KRAS agonist. KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells.

Product Specifications

CAS Number

[10161-87-2]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kra-533.html

Concentration

10mM

Purity

98.73

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=C(CCCCNC(CBr)=O)C=C1

Molecular Formula

C13H16BrNO3

Molecular Weight

314.18

References & Citations

[1]Xu K, et al. Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy [published correction appears in Mol Cancer. 2020 May 20;19 (1) :93]. Mol Cancer. 2019;18 (1) :85. Published 2019 Apr 10.