Berkeleyacetal C

Product Specifications

CAS Number

[959772-67-9]

UNSPSC Description

Berkeleyacetal C, a meroterpenoid compound, shows favorable activity of inhibiting nitrogen oxide (NO) production of macrophages stimulated by lipopolysaccharide (LPS). Berkeleyacetal C exerts anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways[1].

Target Antigen

Endogenous Metabolite; Fungal

Type

Natural Products

Related Pathways

Anti-infection;Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/berkeleyacetal-c.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](C[C@@]3([C@]4([H])[C@@]2([H])C([C@@H](O[C@]4([H])OC3=O)C)=O)C)([H])[C@]5(CO5)C(C(C(C)(O6)C)=CC1=O)=CC6=O

Molecular Weight

442.46

References & Citations

[1]Márquez-Cadena MA, et al. Synthetic Studies toward the Berkeleyacetal Core Architecture. Org Lett. 2021 Nov 15. |[2]Li SS, et al. Berkeleyacetal C, a meroterpenoid isolated from the fungus Penicillium purpurogenum MHZ 111, exerts anti-inflammatory effects via inhibiting NF-κB, ERK1/2 and IRF3 signaling pathways. Eur J Pharmacol. 2017;814:283-293.