Human Adiponectin Antibody (10A10)

Adiponectin is a secreted protein. It is synthesized exclusively by adipocytes and secreted into plasma.Adiponectin is an important adipokine that is involved in the control of fat metabolism and insulin sensitivity,with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities.Adiponectin also antagonizes TNF-alpha by negatively regulating its expression in various tissuessuch as liver and macrophages, and also by counteracting its effects. It inhibits endothelial NF-kappa-B signalingthrough a cAMP-dependent pathway. Adiponectin may play a role in cell growth, angiogenesis and tissueremodeling by binding and sequestering various growth factors with distinct binding affinities, depending on thetype of complex: LMW, MMW or HMW.