(4-NH2)-Exatecan
Product Specifications
UNSPSC Description
(4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs)[1].
Target Antigen
ADC Cytotoxin; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-nh2-exatecan.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5N)=CC6=C1COC([C@]6(O)CC)=O
Molecular Weight
403.43
References & Citations
[1]Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145397/4-NH2-Exatecan-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145397/4-NH2-Exatecan-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2495742-21-5
Available Sizes
Curated Selection
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