(4-NH2) -Exatecan

(4-NH2) -Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2) -Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[2495742-21-5]

Product Name Alternative

AZ14170132

UNSPSC

12352005

Hazard Statement

H301

Target

ADC Payload; Topoisomerase

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-nh2-exatecan.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5N)=CC6=C1COC([C@]6(O)CC)=O

Molecular Formula

C23H21N3O4

Molecular Weight

403.43

Precautions

H301

References & Citations

[1]Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Camptothecins

Available Sizes

Curated Selection

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