(4-NH2) -Exatecan
(4-NH2) -Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2) -Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[2495742-21-5]
Product Name Alternative
AZ14170132
UNSPSC
12352005
Hazard Statement
H301
Target
ADC Payload; Topoisomerase
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-nh2-exatecan.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N2C(C(C(C2)=C3C4=C5CCC3)=NC4=CC=C5N)=CC6=C1COC([C@]6(O)CC)=O
Molecular Formula
C23H21N3O4
Molecular Weight
403.43
Precautions
H301
References & Citations
[1]Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Camptothecins
Available Sizes
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