α-Cyano-4-hydroxycinnamic acid

α-Cyano-4-hydroxycinnamic acid (α-Cyano-4-hydroxycinnamate) is a potent and non-competitive inhibitor of monocarboxylate transporters (MCTs) . α-Cyano-4-hydroxycinnamic acid inhibits mitochondrial pyruvate transporter with a Ki of 6.3 μM. α-Cyano-4-hydroxycinnamic acid is used as a matrix to facilitate peptide ionization in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry applications[1][2].

Product Specifications

CAS Number

[28166-41-8]

Product Name Alternative

α-Cyano-4-hydroxycinnamate

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H335

Target

Monocarboxylate Transporter

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/α-cyano-4-hydroxycinnamic-acid.html

Purity

99.92

Solubility

DMSO : 200 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)/C(C#N)=C/C1=CC=C(O)C=C1

Molecular Formula

C10H7NO3

Molecular Weight

189.17

Precautions

H315, H317, H319, H335

References & Citations

[1]A P Halestrap, et al. The mitochondrial pyruvate carrier. Kinetics and specificity for substrates and inhibitors. Biochem J. 1975 Apr; 148 (1) : 85-96.|[2]Sara Granja, et al. The Monocarboxylate Transporter Inhibitor α-cyano-4-hydroxycinnamic Acid Disrupts Rat Lung Branching. Cell Physiol Biochem. 2013;32 (6) :1845-56.|[3]Makoto Watanabe, et al. Improvement of Mass Spectrometry Analysis of Glycoproteins by MALDI-MS Using 3-aminoquinoline/α-cyano-4-hydroxycinnamic Acid. Anal Bioanal Chem. 2013 May;405 (12) :4289-93.