What is the catalog number for BpV (phen)?

The catalog number for BpV (phen) is HY-136065.

What sizes are available for BpV (phen)?

BpV (phen) is available in the following size(s): 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does BpV (phen) come in?

BpV (phen) is available in 5 different pack sizes.

Is BpV (phen) in stock?

BpV (phen) is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures BpV (phen)?

BpV (phen) is manufactured by QuantiMol.

What is the estimated delivery time for BpV (phen)?

Estimated delivery time for BpV (phen) is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for BpV (phen)?

The safety data sheet for BpV (phen) is available here: http://file.medchemexpress.com/batch_PDF/HY-136065/bpV-phen-SDS-MedChemExpress.pdf.

BpV (phen)

BpV (phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV (phen) inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV (phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ) . bpV (phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity[1][2][3][4][5].

Product Specifications

CAS Number

42494-73-5

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Parasite; Phosphatase; PTEN

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bpv-phen.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=[V+3]12([N]3=CC=C4)([O-][O-]1)([O-][O-]2)[N]5=C6C3=C4C=CC6=CC=C5.[K+]

Molecular Formula

C12H8KN2O5V

Molecular Weight

350.24

Precautions

H315, H319, H335

References & Citations

[1]Tang W, et al. PTEN-mediated mitophagy and APE1 overexpression protects against cardiac hypoxia/reoxygenation injury. In Vitro Cell Dev Biol Anim. 2019 Oct;55 (9) :741-748.|[2]Caron D, et al. Protein tyrosine phosphatase inhibition induces anti-tumor activity: evidence of Cdk2/p27 kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells. Cancer Lett. 2008 Apr 18;262 (2) :265-75.|[3]Schmid AC, et al. Bisperoxovanadium compounds are potent PTEN inhibitors. FEBS Lett. 2004 May 21;566 (1-3) :35-8.|[4] Band CJ, et al. Early signaling events triggered by peroxovanadium [bpV (phen) ] are insulin receptor kinase (IRK) -dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase (s) by bpV (phen) . Mol Endocrinol. 1997 Dec;11 (13) :1899-910.|[5]Chen Q, et al. Potassium Bisperoxo (1,10-phenanthroline) oxovanadate (bpV (phen) ) Induces Apoptosis and Pyroptosis and Disrupts the P62-HDAC6 Protein Interaction to Suppress the Acetylated Microtubule-dependent Degradation of Autophagosomes. J Biol Chem. 2015 Oct 23;290 (43) :26051-8.