Anti-TSHR Monoclonal Antibodies

<strong>Anti-TSHR Monoclonal Antibodies</strong>_x000D_ <strong>Catalog number:</strong> B2010393_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> 150 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Appearance:</strong> Clear Solution_x000D_ <strong>Applications:</strong> Five different Mouse Monoclonal Antibodies specific to human TSH Receptor (TSHR). These antibodies were validated in the detection of TSHR in many applications including WB, IP nd other immunoassays. Available in biotinylated version._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> antibody to human TSHR, anti human TSHR, hTSHR antibody_x000D_ <strong>Grade:</strong> Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Woeller CF, Roztocil E, Hammond C, Feldon SE. TSHR Signaling Stimulates_x000D_ Proliferation Through PI3K/Akt and Induction of miR-146a and miR-155 in Thyroid_x000D_ Eye Disease Orbital Fibroblasts. Invest Ophthalmol Vis Sci. 2019 Oct_x000D_ 1;60(13):4336-4345._x000D_ _x000D_ 2: Diana T, Olivo PD, Kahaly GJ. Thyrotropin Receptor Blocking Antibodies. Horm_x000D_ Metab Res. 2018 Dec;50(12):853-862._x000D_ _x000D_ 3: Furmaniak J, Sanders J, Núñez Miguel R, Rees Smith B. Mechanisms of Action of_x000D_ TSHR Autoantibodies. Horm Metab Res. 2015 Sep;47(10):735-52._x000D_ _x000D_ 4: Pujol-Borrell R, Álvarez-Sierra D, Jaraquemada D, Marín-Sánchez A, Colobran_x000D_ R. Central Tolerance Mechanisms to TSHR in Graves' Disease: Contributions to_x000D_ Understand the Genetic Association. Horm Metab Res. 2018 Dec;50(12):863-870._x000D_ _x000D_ 5: Holthoff HP, Uhland K, Kovacs GL, Reimann A, Adler K, Wenhart C, Ungerer M._x000D_ Thyroid-stimulating hormone receptor (TSHR) fusion proteins in Graves' disease._x000D_ J Endocrinol. 2020 Aug 1;246(2):135-147._x000D_ _x000D_ 6: Qu M, Wan S, Ren B, Wu H, Liu L, Shen H. Association between TSHR gene_x000D_ methylation and papillary thyroid cancer: a meta-analysis. Endocrine. 2020_x000D_ Sep;69(3):508-515._x000D_ _x000D_ 7: Liu T, Men Q, Su X, Chen W, Zou L, Li Q, Song M, Ouyang D, Chen Y, Li Z, Fu_x000D_ X, Yang A. Downregulated expression of TSHR is associated with distant_x000D_ metastasis in thyroid cancer. Oncol Lett. 2017 Dec;14(6):7506-7512._x000D_ _x000D_ 8: Fang Y, Sun F, Zhang RJ, Zhang CR, Yan CY, Zhou Z, Zhang QY, Li L, Ying YX,_x000D_ Zhao SX, Liang J, Song HD. Mutation screening of the TSHR gene in 220 Chinese_x000D_ patients with congenital hypothyroidism. Clin Chim Acta. 2019 Oct;497:147-152._x000D_ _x000D_ 9: Zhou L, Wu K, Zhang L, Gao L, Chen S. Liver-specific deletion of TSHR_x000D_ inhibits hepatic lipid accumulation in mice. Biochem Biophys Res Commun. 2018_x000D_ Feb 26;497(1):39-45._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/24845969/">10: Huth S, Jaeschke H, Schaarschmidt J, Paschke R. Controversial constitutive_x000D_ TSHR activity: patients, physiology, and in vitro characterization. Horm Metab_x000D_ Res. 2014 Jun;46(7):453-61. </a>_x000D_ _x000D_ <strong>Products Related to Anti-TSHR Monoclonal Antibodies</strong><a href="https://moleculardepot.com/product-category/Antibodies/">: Antibodies</a>