4-Hydroxytolbutamide-d9

4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].

Product Specifications

CAS Number

[1185112-19-9]

Product Name Alternative

Hydroxytolbutamide-d9

UNSPSC

12352005

Hazard Statement

H225, H302+H312+H332, H319

Target

Autophagy; Potassium Channel

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Field of Research

Cancer; Metabolic Disease

Purity

99.29

Solubility

Ethanol : 12 mg/mL (ultrasonic; warming)

Smiles

O=S(C1=CC=C(CO)C=C1)(NC(NC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)=O

Molecular Formula

C12H9D9N2O4S

Molecular Weight

295.40

Precautions

H225, H302+H312+H332, H319

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2] Hansen LL, et al. Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Ther Drug Monit. 1999 Dec;21 (6) :664-71.|[3]Yuan R, et al. Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab Dispos. 2002 Dec;30 (12) :1311-9.