Omecamtiv mecarbil

Omecamtiv mecarbil (CK-1827452) is a selective cardiac myosin activator.

Product Specifications

CAS Number

[873697-71-3]

Product Name Alternative

CK-1827452

UNSPSC

12352005

Hazard Statement

H302, H315, H320, H335

Target

Myosin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Omecamtiv-mecarbil.html

Purity

99.83

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1CCN(CC1)CC2=C(C(NC(NC3=CC=C(N=C3)C)=O)=CC=C2)F)OC

Molecular Formula

C20H24FN5O3

Molecular Weight

401.43

Precautions

H302, H315, H320, H335

References & Citations

[1]Morgan BP, et al. Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin. ACS Med Chem Lett. 2010 Aug 20;1 (9) :472-7.|[2]Mamidi R, et al. Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C. J Mol Cell Cardiol. 2015 Aug;85:262-72.|[3]Swenson AM, et al. Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle. J Biol Chem. 2017 Mar 3;292 (9) :3768-3778.