Omecamtiv mecarbil
Product Specifications
UNSPSC Description
Omecamtiv mecarbil (CK-1827452) is a selective cardiac myosin activator.
Target Antigen
Myosin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Omecamtiv-mecarbil.html
Solubility
DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(N1CCN(CC1)CC2=C(C(NC(NC3=CC=C(N=C3)C)=O)=CC=C2)F)OC
Molecular Weight
401.43
References & Citations
[1]Morgan BP, et al. Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin. ACS Med Chem Lett. 2010 Aug 20;1(9):472-7.|[2]Mamidi R, et al. Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C. J Mol Cell Cardiol. 2015 Aug;85:262-72.|[3]Swenson AM, et al. Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle. J Biol Chem. 2017 Mar 3;292(9):3768-3778.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14233/Omecamtiv-mecarbil-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14233/Omecamtiv-mecarbil-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
873697-71-3
Available Sizes
Curated Selection
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