YMU1

YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM. YMU1 inhibits tumor proliferation[1][2].

Product Specifications

CAS Number

[902589-96-2]

UNSPSC

12352005

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ymu1.html

Purity

99.19

Solubility

DMSO : 5.56 mg/mL (ultrasonic; warming; heat to 70°C)

Smiles

O=C(N1CCN(C(CN2SC3=NC(C)=CC(C)=C3C2=O)=O)CC1)OCC

Molecular Formula

C17H22N4O4S

Molecular Weight

378.45

References & Citations

[1]Hu CM, et al. Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair. Cancer Cell. 2012 Jul 10;22 (1) :36-50.|[2]Fengqiang Yu, et al. Knockdown of DTYMK suppresses progression and EMT of lung adenocarcinoma 1 via STAT3 signaling. Europe PMC. 20 Mar 2023, 55 (5) :213-221.