YMU1
YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM. YMU1 inhibits tumor proliferation[1][2].
Product Specifications
CAS Number
[902589-96-2]
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ymu1.html
Purity
99.19
Solubility
DMSO : 5.56 mg/mL (ultrasonic; warming; heat to 70°C)
Smiles
O=C(N1CCN(C(CN2SC3=NC(C)=CC(C)=C3C2=O)=O)CC1)OCC
Molecular Formula
C17H22N4O4S
Molecular Weight
378.45
References & Citations
[1]Hu CM, et al. Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair. Cancer Cell. 2012 Jul 10;22 (1) :36-50.|[2]Fengqiang Yu, et al. Knockdown of DTYMK suppresses progression and EMT of lung adenocarcinoma 1 via STAT3 signaling. Europe PMC. 20 Mar 2023, 55 (5) :213-221.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
Available Sizes
Curated Selection
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