SK1-I
SK1-I (BML-258), an analog of sphingosine, is an isozyme-specific competitive SPHK1 inhibitor with a Ki value of 10 μM[1]. SK1-I shows no activity at SPHK1 PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ or CamK2β. SK1-I enhances autophagy and has antitumor activity[2].
Product Specifications
CAS Number
1072443-89-0
Product Name Alternative
BML-258
UNSPSC
12352005
Target
CaMK; SphK
Type
Reference compound
Related Pathways
Immunology/Inflammation; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sk1-i.html
Purity
98.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC[C@H]([C@H](/C=C/C1=CC=C(C=C1)CCCCC)O)NC
Molecular Formula
C17H27NO2
Molecular Weight
277.40
References & Citations
[1]Melissa R Pitman, et al. Inhibitors of the sphingosine kinase pathway as potential therapeutics. Curr Cancer Drug Targets. 2010 Jun;10 (4) :354-67.|[2]Santiago Lima, et al. TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition. Autophagy. 2018;14 (6) :942-957.|[3]Fiona H Greig, et al. Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse. Eur J Pharmacol. 2019 Jan 5;842:1-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SphK1
Available Sizes
Frequently Asked Questions
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