Human IL-23 alpha & Mouse IL-12 beta Heterodimer (HEK293, His-Avi)
IL-23 alpha and IL-12 beta are the IL-23p19 and IL-12p40 subunits, respectively, composing IL-23 via heterodimerization manner. IL-23 binds to a heterodimeric receptor composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, acts on memory CD4 (+) T cells preferentially[1]. IL-23 also involves in activation of several pathways including p38 MAPK or NF-κB and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A[2]. Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein is produced in HEK293 cells, with a C-Terminal Avi and His-tag.
Product Specifications
Product Name Alternative
Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His-Avi), Human; Mouse, HEK293
UNSPSC
12352202
Type
Recombinant Proteins
Assay Protocol
https://www.medchemexpress.com/cytokines/human-il-23a-mouse-il-12b-heterodimer-protein-hek293-his-avi.html
Molecular Formula
51561&16160 (Gene_ID) Q9NPF7 (R20-P189) &P43432 (M23-S335) (Accession)
Molecular Weight
Approximately 22 kDa (Human IL-23 alpha) & 45-60 kDa (Mouse IL-12 beta), based on SDS-PAGE under reducing conditions, due to the glycosylation.
References & Citations
Shipping Conditions
Room temperature in continental US; may vary elsewhere.
Scientific Category
Recombinant Proteins
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog