Physcion
Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC50 and Kd values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells[1][2][3][4][5].
Product Specifications
CAS Number
[521-61-9]
Product Name Alternative
Parietin; Rheochrysidin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Apoptosis; Autophagy; Bacterial; NF-κB; Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Physcion.html
Concentration
10mM
Purity
99.40
Solubility
DMF : 1 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL|THF : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C=C(C)C=C2O)C(C3=CC(OC)=CC(O)=C13)=O
Molecular Formula
C16H12O5
Molecular Weight
284.26
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
TLR4
Available Sizes
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