Olesoxime
Olesoxime (TRO 19622) is a mitochondrial-targeted neuroprotective compound with mean EC50 value for increasing cell survival is 3.2±0.2 μM.
Product Specifications
CAS Number
22033-87-0
Product Name Alternative
TRO 19622; NSC 21311
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/TRO-19622.html
Purity
99.09
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@@]12C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4([C@]([H])(C)CCCC(C)C)[H])=CC(CC1)=NO
Molecular Formula
C27H45NO
Molecular Weight
399.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Martin LJ, et al. Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Aug;13 (8) :568-80.|[2]Bordet T, et al. Olesoxime (TRO19622) : A Novel Mitochondrial-Targeted Neuroprotective Compound. Pharmaceuticals (Basel) . 2010 Jan 28;3 (2) :345-368|[3]Bordet T, et al. Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J Pharmacol Exp Ther. 2007 Aug;322 (2) :709-20.|[4]Xiao WH, et al. Olesoxime (cholest-4-en-3-one, oxime) : analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel. Pain. 2009 Dec 15;147 (1-3) :202-9
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
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