Olesoxime

Olesoxime (TRO 19622) is a mitochondrial-targeted neuroprotective compound with mean EC50 value for increasing cell survival is 3.2±0.2 μM.

Product Specifications

CAS Number

[22033-87-0]

Product Name Alternative

TRO 19622; NSC 21311

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/TRO-19622.html

Purity

99.09

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C[C@@]12C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@]4([C@]([H])(C)CCCC(C)C)[H])=CC(CC1)=NO

Molecular Formula

C27H45NO

Molecular Weight

399.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Martin LJ, et al. Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Aug;13 (8) :568-80.|[2]Bordet T, et al. Olesoxime (TRO19622) : A Novel Mitochondrial-Targeted Neuroprotective Compound. Pharmaceuticals (Basel) . 2010 Jan 28;3 (2) :345-368|[3]Bordet T, et al. Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J Pharmacol Exp Ther. 2007 Aug;322 (2) :709-20.|[4]Xiao WH, et al. Olesoxime (cholest-4-en-3-one, oxime) : analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel. Pain. 2009 Dec 15;147 (1-3) :202-9