Cycloastragenol

Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties[1][2][3].

Product Specifications

CAS Number

[78574-94-4]

Product Name Alternative

Astramembrangenin; Cyclosieversigenin

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Telomerase

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cycloastragenol.html

Purity

98.0

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

CC1(C)[C@@H](O)CC[C@]2(C3)[C@]43CC[C@]5(C)[C@@H]([C@](C)(O6)CC[C@H]6C(C)(O)C)[C@@H](O)C[C@](C)5[C@]4([H])C[C@H](O)[C@@]12[H]

Molecular Formula

C30H50O5

Molecular Weight

490.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Yu Y, et al. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018;16 (3) :2175-2182. |[2]Li M, et al. Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. Acta Pharmacol Sin. 2020;41 (8) :1025-1032.|[3]Yu Y, et al. Cycloastragenol prevents age-related bone loss: Evidence in d-galactose-treated and aged rats. Biomed Pharmacother. 2020;128:110304.