116-9e

116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg) ’s endogenous ATPase activity and the TAg-mediated activation of Hsp70[1][2].

Product Specifications

CAS Number

[831217-43-7]

Product Name Alternative

MAL2-11B

UNSPSC

12352005

Hazard Statement

H301, H410

Target

DNA/RNA Synthesis; HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/116-9e.html

Purity

98.28

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CCCCCN1C(C)=C(C(NC1=O)C2=CC=C(C=C2)C3=CC=CC=C3)C(OCC4=CC=CC=C4)=O)O

Molecular Formula

C31H32N2O5

Molecular Weight

512.60

Precautions

H301, H410

References & Citations

[1]Christine M Wright, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141 (1) :71-80.|[2]Nitika, et al. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020 Aug 14;10 (1) :13831.