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Clebopride (malate)

Clebopride malate is an orally active dopamine Receptor antagonist. Clebopride malate acts on dopamine D2 receptors and has antiemetic and prokinetic effects. Clebopride malate can be used in the study of functional gastrointestinal disorders[1][2][3].

Product Specifications

CAS Number

57645-91-7

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Clebopride-malate.html

Concentration

10mM

Purity

99.41

Solubility

DMSO : 60 mg/mL (ultrasonic) |H2O : 8.33 mg/mL (ultrasonic)

Smiles

O=C(O)C(O)CC(O)=O.O=C(NC1CCN(CC2=CC=CC=C2)CC1)C3=CC(Cl)=C(N)C=C3OC

Molecular Formula

C24H30ClN3O7

Molecular Weight

507.96

Precautions

H302, H315, H319, H335

References & Citations

[1]Reis-Carneiro D, et al. Clebopride-Associated Movement Disorders. Mov Disord Clin Pract. 2023 Sep 6;10 (10) :1562-1563.|[2]Elliott PN, et al. Substituted benzamides as cerebral dopamine antagonists in rodents. Neuropharmacology. 1977 May;16 (5) :333-42.|[3]Takeda K, et al. Clebopride enhances contractility of the guinea pig stomach by blocking peripheral D2 dopamine receptor and alpha-2 adrenoceptor. J Pharmacol Exp Ther. 1991 May;257 (2) :806-11.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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