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PAR-4 Agonist Peptide, amide (TFA)

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist[1].

Product Specifications

CAS Number

1228078-65-6

Product Name Alternative

PAR-4-AP (TFA) ; AY-NH2 (TFA)

UNSPSC

12352209

Target

Protease Activated Receptor (PAR)

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/PAR-4_Agonist_Peptide,_amide_TFA.html

Purity

99.64

Solubility

DMSO : ≥ 250 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@@H](N)C)=O)C(N2[C@@H](CCC2)C(NCC(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CC3=CC=CC=C3)=O)=O)=O)=O.OC(C(F)(F)F)=O

Molecular Formula

C36H49F3N8O9

Molecular Weight

794.82

References & Citations

[1]Annaházi A, et al. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activatedfeed-back loop in visceral inflammatory pain. Neurogastroenterol Motil. 2012 Jan;24 (1) :76-85, e13.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Citation 01

Mol Nutr Food Res. 2022 Jul;66 (13) :e2200166.|Immunity. 2022 Feb 8;55 (2) :224-236.e5.

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