Citronellol (Standard)

Citronellol (Standard) is the analytical standard of Citronellol. Citronellol (Standard) is an orally active inducer of apoptosis. Citronellol (Standard) can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol (Standard) can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol (Standard) can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol (Standard) exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis[2][4][6][7].

Product Specifications

CAS Number

[106-22-9]

Product Name Alternative

(±) -Citronellol (Standard) ; (±) -β-Citronellol (Standard)

UNSPSC

12352211

Hazard Statement

H315, H319, H335, H402

Target

Apoptosis; Atg8/LC3; Autophagy; ERK; Fungal; Necroptosis; p62; PI3K; Reactive Oxygen Species (ROS) ; Reference Standards; TNF Receptor

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/citronellol-standard.html

Purity

97.16

Solubility

10 mM in DMSO

Smiles

CC(CCC=C(C)C)CCO

Molecular Formula

C10H20O

Molecular Weight

156.27

Precautions

H315, H319, H335, H402

References & Citations

[1]Munir S, et al. The Protective Effect of Citronellol against Doxorubicin-Induced Cardiotoxicity in Rats. Biomedicines. 2023 Oct 18;11 (10) :2820.|[2]Shao J, et al. Citronellol Prevents 6-OHDA-Induced Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Parkinson Disease Model of SH-SY5Y Cells via Modulating ROS-NO, MAPK/ERK, and PI3K/Akt Signaling Pathways. Neurotox Res. 2022 Dec;40 (6) :2221-2237.|[3]Sahli F, et al. Autoxidized citronellol: Free radicals as potential sparkles to ignite the fragrance induced skin sensitizing pathway. Food Chem Toxicol. 2022 Aug;166:113201. |[4]Jayaraj RL, et al. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an in vivo model of Parkinson's disease. Heliyon. 2022 Nov 3;8 (11) :e11434. |[5]Mahmood YS, et al. Protective effect of citronellol in rhabdomyolysis-induced acute kidney injury in mice. J Med Life. 2023 Jul;16 (7) :1057-1061. |[6]Yu WN, et al. Citronellol Induces Necroptosis of Human Lung Cancer Cells via TNF-α Pathway and Reactive Oxygen Species Accumulation. In Vivo. 2019 Jul-Aug;33 (4) :1193-1201. |[7]Pereira Fde O, et al. Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, against Trichophyton rubrum involves inhibition of ergosterol biosynthesis. Pharm Biol. 2015 Feb;53 (2) :228-34.