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RX 801077 (hydrochloride)

RX 801077 hydrochloride (2 BFI) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 hydrochlorideshows anti-inflammation and neuroprotection. RX 801077 hydrochloride has the potential for the research of traumatic brain injury (TBI) [1][2].

Product Specifications

CAS Number

89196-95-2

Product Name Alternative

2 BFI

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Imidazoline Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rx-801077-hydrochloride.html

Purity

99.82

Solubility

DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

Cl[H].C1(C2=CC3=CC=CC=C3O2)=NCCN1

Molecular Formula

C11H11ClN2O

Molecular Weight

222.67

Precautions

H302, H315, H319

References & Citations

[1]Carpéné C, et al. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther. 1995 Feb;272 (2) :681-8.|[2]Ni H, et al. 2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury. Front Neurosci. 2019 Jun 26;13:674.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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