BI8622

[1]Peter S, et al. Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase. EMBO Mol Med. 2014 Dec;6 (12) :1525-41.|[2]S. Kahol and S. Mathur (2023) 29P HUWE1 inhibition has tumor suppressive effect in triple-negative breast cancer cell lines by modulating glycolytic and immune modulatory markers. Annals of oncology, Volume 34, Supplement 4S1484.|[3]Crawford, L. J., et al., (2020) . The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma. Oncogene, 39 (27), 5001–5014.|[4]Yang, Y., et al., (2025) . HUWE1-Mediated Degradation of MUTYH Facilitates DNA Damage and Mitochondrial Dysfunction to Promote Acute Kidney Injury. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 12 (13), e2412250|[5]Lin, I. H., et al., (2024) . Regulation of primary cilia disassembly through HUWE1-mediated TTBK2 degradation plays a crucial role in cerebellar development and medulloblastoma growth. Cell death and differentiation, 31 (10), 1349–1361.