ALK inhibitor 1

ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor. ALK inhibitor 1 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM) [1].

Product Specifications

CAS Number

[761436-81-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Anaplastic lymphoma kinase (ALK) ; FAK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ALK-inhibitor-1.html

Concentration

10mM

Purity

99.16

Solubility

1M HCl : 100 mg/mL (ultrasonic; adjust pH to 1 with HCl) |DMSO : �� 100 mg/mL

Smiles

O=S(C1=C(NC2=C(Br)C=NC(NC3=C(OC)C=C(N4CCN(C)CC4)C=C3)=N2)C=CC=C1)(NC)=O

Molecular Formula

C23H28BrN7O3S

Molecular Weight

562.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Jon E Hawkinson, et al. Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2) . ChemMedChem. 2017 Nov 22;12 (22) :1857-1865.