Suberoyl bis-hydroxamic acid

Suberoyl bis-hydroxamic acid (Suberohydroxamic acid; SBHA) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively[1].Suberoyl bis-hydroxamic acid renders MM cells susceptible to apoptosis and facilitates the mitochondrial apoptotic pathways[2].Suberoyl bis-hydroxamic acid can be used for the study of medullary thyroid carcinoma (MTC) [3].

Product Specifications

CAS Number

[38937-66-5]

Product Name Alternative

Suberohydroxamic acid; SBHA

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/suberoyl-bis-hydroxamic-acid.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 8.33 mg/mL (ultrasonic)

Smiles

O=C(NO)CCCCCCC(NO)=O

Molecular Formula

C8H16N2O4

Molecular Weight

204.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Jiri Neuzil, et al. Sensitization of Mesothelioma to TRAIL Apoptosis by Inhibition of Histone Deacetylase: Role of Bcl-xL Down-Regulation. Biochem Biophys Res Commun. 2004 Jan 30;314 (1) :186-91.|[2]V M Richon, et al. A Class of Hybrid Polar Inducers of Transformed Cell Differentiation Inhibits Histone Deacetylases.Proc Natl Acad Sci U S A|[3]Li Ning, et al. Suberoyl Bishydroxamic Acid Activates notch1 Signaling and Suppresses Tumor Progression in an Animal Model of Medullary Thyroid Carcinoma. Ann Surg Oncol. 2008 Sep;15 (9) :2600-5.