NVS-ZP7-4

NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7) and indicates ER zinc levels. ZIP7 is an active molecular node in the Notch pathway and mediates ferroptosis. NVS-ZP7-4 induces ER stress and exerts a certain ferroptosis-inhibiting effect, reduces Erastin (HY-15763) -induced cell death[1][2].

Product Specifications

CAS Number

[2349367-89-9]

UNSPSC

12352005

Target

Ferroptosis; SLC39 (Zinc Transporter)

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/NVS-ZP7-4.html

Purity

98.85

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C(NC12CCN(C[C@@H](NC3=NC4=CC=C(F)C=C4S3)CC5=CC=CC=C5)CC2)NC6=C1C=CC=C6

Molecular Formula

C28H28FN5OS

Molecular Weight

501.62

References & Citations

[1]Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15 (2) :179-188.|[2]Chen PH, et al. Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell Death Dis. 2021 Feb 19;12 (2) :198.