NVS-ZP7-4
NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7) and indicates ER zinc levels. ZIP7 is an active molecular node in the Notch pathway and mediates ferroptosis. NVS-ZP7-4 induces ER stress and exerts a certain ferroptosis-inhibiting effect, reduces Erastin (HY-15763) -induced cell death[1][2].
Product Specifications
CAS Number
[2349367-89-9]
UNSPSC
12352005
Target
Ferroptosis; SLC39 (Zinc Transporter)
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/NVS-ZP7-4.html
Purity
98.85
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C(NC12CCN(C[C@@H](NC3=NC4=CC=C(F)C=C4S3)CC5=CC=CC=C5)CC2)NC6=C1C=CC=C6
Molecular Formula
C28H28FN5OS
Molecular Weight
501.62
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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