ML254

ML254 is a potent mGlu5 potentiator, with EC50 and pEC50 of 9.3 nM and 8.03 nM for rat mGlu5, respectively. ML254 can be used for researching schizophrenia[1]. ML254 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[1428630-86-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ml254.html

Purity

97.05

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1(C)COC1)C2=NC=C(C#CC3=CC=CC(F)=C3)C=C2

Molecular Formula

C18H15FN2O2

Molecular Weight

310.32

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Turlington M, Noetzel MJ, Chun A, et al. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs) : discovery of 5- ((3-fluorophenyl) ethynyl) -N- (3-methyloxetan-3-yl) picolinamide (ML254) . J Med Chem. 2013;56 (20) :7976-7996.