MRK-740
MRK-740, a chemical probe, is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC50 of 80?nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4 (IC50?=?0.8?μM) [1].
Product Specifications
CAS Number
[2387510-80-5]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mrk-740.html
Purity
99.84
Solubility
DMSO : 40 mg/mL (ultrasonic; warming)
Smiles
CC1=NC=CC(N(CC2)CCC32CN(C4=NC(C5=CC(OC)=CC(OC)=C5)=NO4)CCN3C)=C1
Molecular Formula
C25H32N6O3
Molecular Weight
464.56
References & Citations
[1]Abdellah Allali-Hassani, et al. Discovery of a Chemical Probe for PRDM9. Nat Commun. 2019 Dec 17;10 (1) :5759.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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