Smad1 (Phospho Ser214) rabbit pAb
Function: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). PTM: Phosphorylated on serine by BMP type 1 receptor kinase. PTM: Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1. similarity: Belongs to the dwarfin/SMAD family. similarity: Contains 1 MH1 (MAD homology 1) domain. similarity: Contains 1 MH2 (MAD homology 2) domain. subcellular location: Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. subunit: Interacts with HGS, NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1. tissue specificity: Ubiquitous. Highest expression seen in the heart and skeletal muscle.
Product Specifications
Background
Synonyms
Gene ID
4086
UniProt
Q15797
Cellular Locus
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human Smad1 (Phospho Ser214)
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC
Validated Applications
WB,IHC
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:500-2000; IHC-p 1:50-300
Molecular Weight
51kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES20159-1.pdf
Observed Molecular Weight
51 kD
Subcellular Location
Other Product Names
Gene ID (Human)
4086
SwissProt (Human)
Q15797
Available Sizes
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