Smad1 (Phospho Ser214) rabbit pAb

Function: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). PTM: Phosphorylated on serine by BMP type 1 receptor kinase. PTM: Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1. similarity: Belongs to the dwarfin/SMAD family. similarity: Contains 1 MH1 (MAD homology 1) domain. similarity: Contains 1 MH2 (MAD homology 2) domain. subcellular location: Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. subunit: Interacts with HGS, NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1. tissue specificity: Ubiquitous. Highest expression seen in the heart and skeletal muscle.