GSK-3β inhibitor 20

GSK-3β inhibitor 20 (compound 3A) is an potent inhibitor of GSK-3β with an IC50 value of 74.4 nM[1].

Product Specifications

CAS Number

[3044109-48-7]

UNSPSC

12352211

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gsk-3β-inhibitor-20.html

Smiles

O=C(NC1=CC=CC=C1)NC2=CC(C3=CC(NN=C4NC(C(C)C)=O)=C4S3)=CC=C2

Molecular Formula

C22H21N5O2S

Molecular Weight

419.50

References & Citations

[1]Ning Yan, et al. Design, synthesis and biological evaluation of thieno[3,2-c]pyrazol-urea derivatives as potent glycogen synthase kinase 3β inhibitors based on the DFG-out conformation. Bioorg Med Chem Lett. 2024 Nov 1:112:129932.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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