VT-105

VT-105 is a TEAD inhibitor and VT104 (HY-134956) analog. VT-105 binds to the central hydrophobic pocket of the TEAD3 protein. VT-105 can be used in the research of NF2-deficient malignant mesothelioma[1][2].

Product Specifications

CAS Number

[2417718-38-6]

UNSPSC

12352005

Target

YAP

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vt-105.html

Purity

99.93

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C[C@@H](C1=CC=CC=N1)NC(C2=CC3=C(N=C2)C(C4=CC=C(C=C4)C(F)(F)F)=CC=C3)=O

Molecular Formula

C24H18F3N3O

Molecular Weight

421.41

References & Citations

[1]Tang TT, et al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20 (6) :986-998.|[2]Hu L, et al. Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. Elife. 2022 Nov 18;11:e80210.