α-Amylase/α-Glucosidase-IN-10
Product Specifications
UNSPSC Description
α-Amylase/α-Glucosidase-IN-10 (compound 5d) is an α-amylase and α-glucosidase inhibitor (IC50: 30.39 μM and 65.1 μM) with potential diabetes inhibitory effects. α-Amylase/α-Glucosidase-IN-10 exhibits high gastrointestinal (GI) absorption in ADMET (Absorption, Distribution, Metabolism, Excretion and Toxicity) prediction. While α-Amylase/α-Glucosidase-IN-10 acts as a substrate for P-gp and does not cross the blood-brain barrier (BBB), there may be a risk of central nervous system side effects[1].
Target Antigen
Amylases; Glycosidase; P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/α-amylase-α-glucosidase-in-10.html
Solubility
10 mM in DMSO
Smiles
O=C(/C1=N\NC(COC2=C(C)C=CC=C2C[C@H]3ON([C@]4(C[C@H](C)CC[C@H]4C(C)C)N(C)C5=O)[C@@]5([H])C3)=O)NC6=C1C=CC(Cl)=C6
Molecular Weight
622.15
References & Citations
[1]Ghannay S, et al. Identification of dual-target isoxazolidine-isatin hybrids with antidiabetic potential: Design, synthesis, in vitro and multiscale molecular modeling approaches. Heliyon. 2024 Feb 11;10(4):e25911.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162373/α-Amylase-α-Glucosidase-IN-10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162373/
Clinical Information
No Development Reported
Curated Selection
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