AMPte-Glu-γ-Glu
AMPte-Glu-γ-Glu is a substrate for folylpoly-γ-glutamate synthetase (FPGS) . AMPte-Glu-γ-Glu exhibits cytotoxicity against chinese hamster ovaries cells, with IC50s of 20, 350 and 3 nM, for Pro3, R2, and 43-10, respectively[1].
Product Specifications
CAS Number
41600-13-9
UNSPSC
12352005
Target
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ampte-glu-γ-glu.html
Solubility
10 mM in DMSO
Smiles
O=C(CC[C@H](NC(CC[C@H](NC(C1=CC=C(C=C1)N(C)CC2=NC3=C(N=C(N=C3N=C2)N)N)=O)C(O)=O)=O)C(O)=O)O
Molecular Formula
C25H29N9O8
Molecular Weight
583.55
References & Citations
[1]Feng Y, et al., Prodrug forms of N-[ (4-deoxy-4-amino-10-methyl) pteroyl]glutamate-gamma-[psiP (O) (OH) ]-glutarate, a potent inhibitor of folylpoly-gamma-glutamate synthetase: synthesis and hydrolytic stability. J Med Chem. 2006 Jan 26;49 (2) :770-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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